Clinical Research Database

CONCLUSION: This results provide the first demonstration of the existence of PANoptotic neuronal death in cerebral I/R conditions. Curcumin preconditioning enhanced the ameliorating effect of OM-MSCs on neuroinflammation mediated by microglia polarization via upregulating the abundance of miRNA-423-5p. This intervention effectively alleviates PANoptotic neuronal death [...]

Physicochemical properties of nanoparticles, such as particle size, surface charge, and particle shape, have a significant impact on cell activities. However, the effects of surface functionalization of nanoparticles with small chemical groups on stem cell behavior and function remain understudied. Herein, we incorporated different chemical [...]

Epithelial organoid monoculture is a powerful tool to model stem cell dynamics in vitro. However, extensive efforts have recently revealed various niche players and their significant roles in regulating epithelial stem cells. Among these niche components, fibroblasts have been heavily recognized in the field as [...]

Premature ovarian failure (POF) affects many adult women less than 40 years of age and leads to infertility. Mesenchymal stem cells-derived small extracellular vesicles (MSCs-sEVs) are attractive candidates for ovarian function restoration and folliculogenesis for POF due to their safety and efficacy, however, the key [...]

Articular cartilage tissue has limited self-repair capabilities, with damage frequently progressing to irreversible degeneration. Engineered tissues constructed through bioprinting and embedded with stem cell aggregates offer promising therapeutic alternatives. Aggregates of bone marrow mesenchymal stromal cells (BMSCs) demonstrate enhanced and more rapid chondrogenic differentiation than [...]

Bone marrow-derived cells (BMDCs) are heterogeneous populations in which not only pluripotent stem cells, namely, hematopoietic stem cells (HSCs), mesenchymal stem cells (MSC) but also endothelial progenitor cells (EPC) are involved. BMDCs contribute to the maintenance of homeostasis and recovery from disrupted homeostasis as the [...]

CONCLUSION: Our findings confirmed that the exposure of TLR3/4-activated-MSCs-CMs with glioma tumour cells possibly changes the immunogenicity of the tumour microenvironment and induces immunogenic programmed cell death. Our results can support the idea that TLR3/4-primed-MSCs can lead to innate immune-mediated cell death and modify tumour [...]

Facile and rapid 3D fabrication of strong, bioactive materials can address challenges that impede repair of large-to-massive rotator cuff tears including personalized grafts, limited mechanical support, and inadequate tissue regeneration. Herein, we developed a facile and rapid methodology that generates visible light-crosslinkable polythiourethane (PHT) pre-polymer [...]

Osteogenesis is a complex process of bone formation regulated by various factors, yet its underlying molecular mechanisms remain incompletely understood. The present study aimed to investigate the role of S100A16, a novel member of the S100 protein family, in the osteogenic differentiation of rat bone [...]

CONCLUSION: Data from controlled trials suggest that stem cell transplantation as a therapy for Parkinson's disease can be effective for at least 12 months. The factors that may influence its curative effect are time after transplantation and stem cell types. [...]

Acquired generalized lipodystrophy (AGL) is an extremely rare disease that is characterized by loss of body fat affecting nearly all parts of the body. It is often associated with autoimmune diseases or panniculitis, whereas in other patients the underlying etiology is unclear. We report a [...]

CONCLUSIONS: HPMSCs-Exo represents a protective regimen against endothelial barrier disruption of HPVECs in ALI/ARDS, and the hsa-miR-148a-3p/ROCK1 pathway plays an important role in this therapeutics implication. [...]

CONCLUSION: scATAC-seq can be used to assess heterogeneity in glioblastoma and identify cells with high stemness characteristics. The package is publicly available at https://github.com/Necla/StemnesScoRe and includes documentation with implementation of a real-data experiment. [...]

Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a cellular immune response whereby glial cells are activated, inflammatory mediators are liberated and reactive oxygen and nitrogen species are [...]

Over the last decades, there has been ongoing and evolving research concerning regenerative medicine, specifically, stem cells. The most common source of adult mesenchymal stem cells (MSCs) remains the adipose tissue and the easiest way to obtain such tissue is lipoaspirate. The fatty tissue obtained [...]

Biomechanical cues could effectively govern cell gene expression to direct the differentiation of specific stem cell lineage. Recently, the medium viscosity has emerged as a significant mechanical stimulator that regulates the cellular mechanical properties and various physiological functions. However, whether the medium viscosity can regulate [...]

Conditions: Heart Failure With Reduced Ejection Fraction Interventions: Dietary Supplement: 3-hydroxybutyrat; Dietary Supplement: Isocaloric placebo drink Sponsors: Aarhus University Hospital Recruiting [...]

Conditions: Multiple Myeloma Interventions: Biological: idecabtagene vicleucel; Drug: Lenalidomide; Drug: Fludarabine; Drug: Cyclophosphamide Sponsors: Celgene; Bristol-Myers Squibb Recruiting [...]

Conditions: Prostate Cancer Interventions: Diagnostic Test: NeuroSAFE procedure; Diagnostic Test: LaserSAFE procedure Sponsors: University College, London; University College London Hospitals Not yet recruiting [...]

Conditions: Haematological Malignancy Interventions: Other: Detection of donor-specific anti-HLA antibody (DSA) Sponsors: Peking University People's Hospital Not yet recruiting [...]

Conditions: Transplant-Related Disorder; GVH - Graft Versus Host Reaction Interventions: Device: CliniMACS® CD34 TCR Alpha/Beta Sponsors: Victor Aquino Temporarily not available [...]

Conditions: Fibromyalgia; Fatigue; Fatigue; Muscle, Heart; Strength Training; Stress Interventions: Behavioral: FMG (Fibromyalgia group); Behavioral: HG (Healthy group) Sponsors: Catholic University of Murcia; Universidad de Extremadura Not yet recruiting [...]

Conditions: Large Cell Neuroendocrine Carcinoma of the Lung Interventions: Drug: Durvalumab with etoposide and Carboplatin/Cisplatin Sponsors: Centre Leon Berard; Groupe Français de Pneumo-Cancérologie Not yet recruiting [...]

Conditions: B-cell Acute Lymphoblastic Leukemia Interventions: Drug: Decitabine, venetoclax and blinatumomab Sponsors: The First Affiliated Hospital of Soochow University Not yet recruiting [...]